United States: A new analysis concludes that GLP-1 receptor agonist promotes the sensation of satiety before meals through neurons within the dorsomedial hypothalamus. 

More about the finding 

The study provides new knowledge regarding the neurological function through which GLP-1 receptor agonists enhance the level of satiety to address this issue of overeating, which is central to the prevention of obesity. 

Therefore, it is crucial to signal the feeling of satiety or fullness after eating, among them being glucagon-like peptide-1 (GLP-1). 

Preingestive satiation is a true hunger control that takes place before the ‘real’ eating so that permanent internal status regulation and changes are possible. 

GLP-1 Drugs Fight Obesity by Boosting Pre-Meal Satiety. Credit | GettyImages
GLP-1 Drugs Fight Obesity by Boosting Pre-Meal Satiety. Credit | GettyImages

More recently, the efficacy of GLP-1 receptor agonists (GLP-1RAs) has been demonstrated for obesity treatment; GLP-1RAs exerted influences on food cognition, reduced hypothalamic activity in response to food prompts, and shifted food palatability, as neurosciencenews.com reported. 

What more have the findings suggested? 

Therefore, it can be inferred that GLP-1RAs have preingestive satiation for regulating food intake. 

Nevertheless, the appearance of these effects depends on different factors, and the targets of GLP-1RAs still need to be determined. 

Here, Kyu Sik Kim and colleagues describe the outcomes of clinical trials of obese people based on the phase. 

Baseline, pre-ingestive, and ingestive satiation surveys were completed with or without GLP-1RA on the planned diet except for the treat meal. 

The main parameters of this study were evaluated as follows: GLP-1RA treatment resulted in a statistically significant increased satiation index (overall feeling of fullness) at all phases of the study, while the control group profile demonstrated a significant decline from baseline at the pre-ingestive phase level. 

During the pre-ingestive phase, GLP-1RA significantly changed the satiation index compared with the baseline and improved the steps of prospective food ingestion, food reward, and the motivation satiation index, as neurosciencenews.com reported. 

In their research, Kim and others studied brain tissues from both humans and mice to determine circuits that are involved in the interaction between the dorsomedial hypothalamus and these agonists that enables the reduction of food desire. 

Activation of these neurons using optogenetics leads to satiation, while calcium imaging suggests that these neurons are involved in the encoding of preingestive satiation. 


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